Separation and purification process development_Technology Application_Shandong Bona Biotechnology Group Co., Ltd.

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Separation and purification process development

Paclitaxel Resin for extraction, separation and purification process of taxol

Paclitaxel Resin for extraction, separation and purification process of taxol

Release time：

2019.09.24

Paclitaxel (trade name Taxo1) is a unique anti-tumor natural drug in Taxus plants. It was first isolated in 1971 by American chemists Wani and Wallt, and was officially approved by the US FDA in 1992. New anti-ovarian cancer drug.

Chromatography packing for extraction, separation and purification of ascomycin (ascomycin, immunomycin, FK520)

Release time：

2019.09.24

Ascomycin (ascomycin, immunomycin, FK520) is a twenty-three carbon macrolide compound, an ethyl analog of the immunosuppressant tacrolimus (FK-506), and a synthetic pimecrolimus (Trade name Elidel) precursor material.

Organic acid separation and purification packing

Release time：

2019.09.24

Organic acids, such as citric acid, tartaric acid, malic acid, and ascorbic acid, are mostly combined with metal ions or combined with alkaloids to form salts. They are very effective active ingredients of Chinese herbal medicines.

Reverse chromatography medium for thymus method new separation and purification reverse chromatography packing reverse chromatography resin packing

Release time：

2019.09.24

Thymosin α1 (Thymosin) is a 28 peptide with strong acidity, with a molecular weight of 3108 and an isoelectric point of 4.2. The N-terminal is acetylated. The synthesized crude peptide contains many impurities with molecular size and properties similar to the product, which is not easy to purify.

Alkaloid separation and purification packing

Release time：

2019.09.24

Alkaloids are nitrogen-containing organic compounds derived from the plant kingdom. They are very effective active ingredients of Chinese herbal medicines. The effect on traditional silica gel or alumina chromatography is often not ideal.

Nemadectin (Nemadectin) Moxidectin (Moxidectin) extraction separation and purification chromatography packing SKP10N

Release time：

2019.09.24

Nemadectin (Nemadectin) is a 16-membered macrolide antibiotic, produced by Streptomyces cyaneogriseus sp. Noncyanogenus through fermentation process.

Resin filler for separation and purification of daunorubicin, epirubicin, adriamycin, epirubicin, pirarubicin

Release time：

2019.09.24

For such products with similar structures, the SKP-20-4300 chromatography resin developed by Jinan Bona Biotechnology Co., Ltd. can solve the difficulty of separation and purification of the final product, and control the single impurity in the product below 0.1% without repeated crystallization.

Chromatography packing for Huperzine extraction, separation and purification SKP-10-4100 SKR-10-4100

Release time：

2019.09.24

Huperzine A is a potent and reversible cholinesterase inhibitor, which is good for treating myasthenia gravis, improving memory decline in the elderly, and improving the memory and cognitive behavioral functions of Alzheimer's patients.

Separation and purification service

Release time：

2019.09.24

After years of technical practice, Bona Bio has accumulated a large number of efficient separation and purification methods and technologies, and developed technologies and methods for rapid and economical separation and purification of complex drug mixtures, natural products and biological samples.

Vancomycin extraction, separation and purification process

Release time：

2019.09.24

Vancomycin is a glycopeptide antibiotic isolated from the fermentation broth of a strain of Streptomycin orientalis by Micormick in 1956. It was approved by the US FDA in 1958 and was developed and marketed by Lilly.

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